Standard drug tests, such as the SAMHSA-5, do not detect kratom. Kratom's primary alkaloids, Mitragynine and 7-hydroxymitragynine, are structurally different from substances tested in typical drug panels, such as those for THC, opiates, amphetamines, cocaine, and PCP. Still, these are not commonly used unless there's a specific reason to test for kratom. For instance, in some occupational settings or legal scenarios where kratom use might be suspected or relevant, these tests might be administered. Also, while rare, there have been anecdotal reports of kratom use leading to false positives for certain substances, particularly opioids. However, false positives can be clarified with a confirmation test, like GC/MS (gas chromatography/mass spectrometry).